diabities, diabetes info, diabetes effects,diabetes two,dibetes | Intensive Diabetic Control = Reduced Kidney Damage

Intensive Diabetic Control = Reduced Kidney Damage

Intensive lowering of blood HbA1c levels to 6.5 percent can safely and effectively reduce serious diabetes complications like nephropathy, says senior
consultant endocrinologist Professor Chan
Siew Pheng.

Professor Chan was principal investigator of the
ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release

Controlled Evaluation Trial) team at the University of Malaya
Medical Centre, one of the five participating
centers in Malaysia.

“What we can say from ADVANCE1 is
that if we lower blood sugar safely towards
normal, without causing hypoglycemia and
weight gain, we can reduce the complications
from diabetes,” Chan told the audience
in a media tutorial organized by Servier
Malaysia, to announce the results of the
ADVANCE blood glucose arm.

“Importantly, we did not see an excess of
death from improving glucose control down
to normal. I think that is a very important
point. And although we did not see a clear
benefit in terms of reducing heart attacks or
stroke, we did not cause more harm to our
patients.”

The ADVANCE glucose arm showed a
significant reduction in the risk of serious
complications among intensively controlled
patients – a 10 percent relative risk reduction
in combined major macro- and microvascular
events.

Chan said this reduction was mainly due
to the 21 percent relative decrease in new or
worsening nephropathy in patients treated
intensively. Severe proteinuria was noted reduced in intensively controlled diabetes patients.

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